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KMID : 0386120010440060733
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Journal of the Korean Radiological Society
2001 Volume.44 No. 6 p.733 ~ p.741
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Analysis of Signal Intensity Curve on Dynamic Contrast-Enhanced MR Imaging of Postoperative Scars in Rabbits:Comparison of Gadopentetate Dimeglumine and 24-gadolinium-tetraazacy-clododecanetetraacetic acid (DOTA)-dendrimer
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이준우:Lee Joon-Woo
문우경:Moon Woo-Kyung/장기현:Chang Kee-Hyun/김수정:Kim Soo-Jeoung/김종효:Kim Jong-Hyo/김태정:Kim Tae-Jeong/최준일:Choi Joon-Il/김세형:Kim Se-Hyung/권종원:Kwon Chong-Won/최보윤:Choi Bo-Yoon/김효철:Kim Hyo-Cheol/:Weinmann Hanns-Joachim
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Abstract
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Purpose: To compare the enhancement patterns of 24-gadolinium-tetrazacyclodode-cane tetracetic acid (DOTA)-dendrimer (Gadomer-17) with those of gadopentetate dimeglumine (Magnevist) in postoperative scars in rabbits.
Materials and Methods: Twelve rabbit thighs with experimentally induced postopera-tive scars underwent dynamic contrast-enhanced MR imaging with both Gadomer-17 and gadopentetate dimeglumine at a 24-hr interval at one (n = 10), two (n = 8) and three months (n=4) after scar induction. The enhancement and the ratios of lesions at each time point, peak enhancement ratios, and the slope and shape of curves were as-sessed.
Results: At all time points, enhancement ratios were significantly lower after the injection of Gadomer-17 than with gadopentetate dimeglumine (p<0.05). Peak enhance-ment ratios were significantly lower with Gadomer-17 (1.29 ±0.15) than with gadopentetate dimeglumine (1.61 ±0.31) (p<0.01). The slope values were 2.99%/min ±2.72 after Gadomer-17 injection and 8.99%/min ±7.32 after gadopentetate dimeglumine injection (p<0.01). The enhancement ratio curves showed mostly the plateau pattern with Gadomer-17 (90.9%), while for gadopentetate dimeglumine, the curve pattern was either plateau (50%) or washout (50%). Difference in enhancement char-acteristics between the two contrast agents were most pronounced for one-month scars.
Conclusion: With Gadomer-17, weaker enhancement and the plateau pattern were found in postoperative scars, whereas stronger enhancement and either washout or the plateau pattern were found with gadopentetate dimeglumine.
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KEYWORD
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Magnetic resonance (MR), experimental studies, Magnetic resonance (MR), contrast enhancement, Animals,
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